Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review.

ABSTRACT:

Objectives

Evidence-based protocols for managing bleeding emergencies in patients with immune thrombocytopenia (ITP) are lacking. We conducted a systematic review of treatments for critical bleeding in patients with ITP.

Methods

We included all study designs and extracted data in aggregate or individually for patients who received one or more interventions and for whom any of the following outcomes were reported: platelet count response, bleeding, disability, or death.

Results

We identified 49 eligible studies reporting 112 critical bleed patients with ITP, including 66 children (median age, 10 years), 36 adults (median age, 41.5 years), and 10 patients with unreported age. Patients received corticosteroids (n = 67), IVIG (n = 49), platelet transfusions (n = 41), TPO-

SUBMITTER: Chowdhury SR 

PROVIDER: S-EPMC11798764 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature