Lipid-lowering drug targets associated with risk of respiratory disease: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have identified a possible connection between lipid-lowering medications and respiratory illnesses. However, it remains unclear whether lipid-lowering drugs is causative for respiratory diseases, and we aimed to answer this question.

Methods

We performed Mendelian randomization (MR) analyses by integrating data from genome-wide association studies (GWAS). Three statistical approaches were employed for MR analysis: inverse variance weighting (IVW), MR-Egger, and weighted median. The purpose was to evaluate the causal relationships between 10 drug targets that lower lipid levels and the likelihood of developing 7 respiratory diseases. Additional sensitivity analyses were conducted to ensure the robustness and validity of the results.

Results

SUBMITTER: Gong Z 

PROVIDER: S-EPMC11817876 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature