Andrographolide reverses the susceptibility of Streptococcus suis to aminoglycoside antibiotics by proton motive force.

ABSTRACT:

Background

The global rise in multidrug-resistant bacteria has significantly undermined the efficacy of traditional antibiotics. Multidrug-resistant Streptococcus suis (S. suis), a pathogen capable of infecting pigs and humans, has been identified as a critical threat, causing severe meningitis and rapid mortality. In response, researchers have increasingly focused on herbal compounds as non-traditional antimicrobial agents, which can inhibit bacterial growth while minimizing the risk of resistance development. This study investigates the mechanism through which andrographolide (AP) restores the susceptibility of S. suis to aminoglycoside antibiotics.

Methods

The intracellular ΔpH in S. suis was assessed using the 2',7' -bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (BCC

SUBMITTER: Xue B 

PROVIDER: S-EPMC11823085 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature