Novel endoscopic scoring system for immune mediated colitis: a multicenter retrospective study of 674 patients.

ABSTRACT:

Background and aims

No endoscopic scoring system has been established for immune-mediated colitis (IMC). This study aimed to establish such a system for IMC and explore its utility in guiding future selective immunosuppressive therapy (SIT) use compared to clinical symptoms.

Methods

This retrospective, international, 14-center study included 674 patients who developed IMC after immunotherapy and underwent endoscopic evaluation. Ten endoscopic features were selected by group consensus and assigned 1 point each to calculate an IMC endoscopic score (IMCES). IMCES cutoffs were chosen to maximize specificity for SIT use. This specificity was compared between IMCESs, and clinical symptoms were graded according to a standardized instrument.

Results

A total of 309 (45.8%) pat

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11832009 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature