Clinical Correlates of Efficacy of Pyridostigmine in the Treatment of Orthostatic Hypotension.

ABSTRACT:

Background

The cholinesterase inhibitor pyridostigmine is used to treat orthostatic hypotension by facilitating cholinergic neurotransmission in autonomic ganglia, thereby harnessing residual sympathetic tone to increase blood pressure (BP) preferentially in the upright posture. We hypothesized that less severe autonomic impairment was associated with greater pressor responses to pyridostigmine.

Methods

To identify predictors of pressor response, linear regression analyses between the effect of pyridostigmine on upright BP and markers of autonomic impairment were retrospectively conducted on 38 patients who had a medication trial with pyridostigmine (60 mg single dose).

Results

Pyridostigmine increased upright BP by 4±2/3±2 mm Hg but with a wide range of responses (-2

SUBMITTER: Okamoto LE 

PROVIDER: S-EPMC11839338 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature