Function-Specific Localization in the Supplementary Motor Area: A Potential Effective Target for Tourette Syndrome.

ABSTRACT:

Aims

Repetitive transcranial magnetic stimulation (rTMS) targeting the supplementary motor area (SMA) may treat Tourette's syndrome (TS) by modulating the function of the globus pallidus internus (GPi) via the cortico-striato-thalamo-cortical circuit.

Methods

We conducted a randomized longitudinal study to examine circuit functionality and clinical efficacy. The GPi was identified as an "effective region" for TS treatment. Using functional MRI, individualized targets within the SMA were identified. Function-specific targets [left SMA (n = 19), right SMA (n = 16)] were compared with conventional scalp-localized SMA targets (n = 19). Age- and gender-matched typical developmental children (TDC) served as controls (n = 48). TS patients received 50 Hz continuous theta burst stimu

SUBMITTER: Wang J 

PROVIDER: S-EPMC11843473 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature