Opportunistic assessment of steatotic liver disease in lung cancer screening eligible individuals.

ABSTRACT:

Background

Steatotic liver disease (SLD) is a potentially reversible condition but often goes unnoticed with the risk for end-stage liver disease.

Purpose

To opportunistically estimate SLD on lung screening chest computed tomography (CT) and investigate its prognostic value in heavy smokers participating in the National Lung Screening Trial (NLST).

Material and methods

We used a deep learning model to segment the liver on non-contrast-enhanced chest CT scans of 19,774 NLST participants (age 61.4 ± 5.0 years; 41.2% female) at baseline and on the 1-year follow-up scan if no cancer was detected. SLD was defined as hepatic fat fraction (HFF) ≥5% derived from Hounsfield unit measures of the segmented liver. Participants with SLD were categorized as lean (body mass index [B

SUBMITTER: Weiss J 

PROVIDER: S-EPMC11846076 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature