Plasmodium falciparum gametocyte burden in a Tanzanian heterogeneous transmission setting.

ABSTRACT:

Background

Malaria transmission depends on the presence of gametocytes in the peripheral blood of infected human hosts. Understanding malaria infectious reservoirs enables transmission-blocking interventions to target the most important hosts for the disease. This study characterized the distribution of gametocyte carriage as a baseline for the clinical evaluation of a Pfs25-based transmission-blocking vaccine candidate in Bagamoyo, Tanzania.

Methods

A malaria survey was conducted in five locations from May to August 2022. A total of 467 participants-192 children (5-12 years), 65 adolescents (13-17 years) and 210 adults (18-45 years)-were enrolled. Malaria was detected using three methods: rapid diagnostic tests, light microscopy and quantitative polymerase chain reaction. T

SUBMITTER: Mulamba C 

PROVIDER: S-EPMC11846475 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature