Elevated Serum Levels of Acid Sphingomyelinase in Female Patients with Episodic and Chronic Migraine.

ABSTRACT: Migraine is one of the most common neurological disorders and the second most disabling human condition. The molecular mechanisms of migraine have been linked to neuropeptide release, endothelial dysfunction, oxidative stress and inflammatory processes. Acid sphingomyelinase (aSMase) is a secreted enzyme that leads to sphingomyelin degradation to produce ceramide. Its activity has been associated with several molecular processes involved in migraine. Therefore, this cross-sectional study aims to study the potential role of aSMase in patients with episodic and chronic migraine. In this cross-sectional pilot study, serum samples from female healthy controls (n = 23), episodic migraine (EM) patients (n = 31), and chronic migraine (CM) patients (n = 28) were studied. The total serum levels of

SUBMITTER: Ouro A 

PROVIDER: S-EPMC11851676 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature