Possible interrelationship between vitamins E and b12 in the disturbance in methylmalonate metabolism in vitamin E deficiency.
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ABSTRACT:
SUBMITTER: Pappu AS
PROVIDER: S-EPMC1185669 | biostudies-literature | 1978 Apr
REPOSITORIES: biostudies-literature
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Possible interrelationship between vitamins E and b12 in the disturbance in methylmalonate metabolism in vitamin E deficiency.
Pappu A S AS Fatterpaker P P Sreenivasan A A
The Biochemical journal 19780401 1
1. The disturbance in 2-methylmalonate metabolism resulting in its increased urinary excretion observed in vitamin E deficiency is not caused by increased formation of methylmalonate from propionate as is evident from the activity of the enzyme propionyl-CoA carboxylase (EC 6.4.1.3), but can be traced to an impairment in the conversion of methylmalonate into succinate by the vitamin B12-requiring enzyme, methylmalonyl-CoA mutase (EC 5.4.99.2) in rat liver. 2. It is shown that the decrease in the ...[more]
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