Precise placement of thioester bonds into sequence-controlled polymers containing ABAC-type units.

ABSTRACT: The precise placement of thioester bonds into sequence-controlled polymers remains a grand challenge. Here, we demonstrate the versatile synthesis of sequence-controlled polymers from the step polymerization of cyclic thioanhydrides (A), diacrylates (B), and diols/diamines (C). In addition to easily accessible diverse monomers, the method is metal-free/catalyst-free, atom-economical, and wide in monomer scope, yielding 107 polymers with >90% yields and weight-average molecular weights of up to 175.4 kDa. The obtained polymers contain ABAC-type repeating units and precisely distributed in-chain thioester and ester (and amide) groups. The chemoselectivity of the polymerization is revealed by density functional theory calculations. The polymer library exhibits considerably tunable performance

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11862183 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature