Independent associations of high-density lipoprotein cholesterol and triglyceride levels with Alzheimer's disease and related dementias.

ABSTRACT:

Introduction

We evaluated the independent associations between high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels with Alzheimer's disease and related dementias (ADRD).

Methods

Among 177,680 members of Kaiser Permanente Northern California who completed a survey on health risks, we residualized TGs and HDL-C conditional on age, sex, and body mass index. We included these residuals individually and concurrently in Cox models predicting ADRD incidence.

Results

Low (hazard ratio [HR] 1.06, 95% confidence interval [CI] 1.02-1.10) and high quintiles (HR 1.07, 95% CI 1.03-1.12) of HDL-C residuals were associated with an increased risk of ADRD compared to the middle quintile. Additional adjustment for TGs attenuated the association with high HDL-C (HR

SUBMITTER: Ferguson EL 

PROVIDER: S-EPMC11863358 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature