Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca²⁺ handling across the adult lifespan in men.

ABSTRACT: Aging-related muscle atrophy and weakness contribute to loss of mobility, falls, and disability. Mitochondrial dysfunction is widely considered a key contributing mechanism to muscle aging. However, mounting evidence positions physical activity as a confounding factor, making unclear whether muscle mitochondria accumulate bona fide defects with aging. To disentangle aging from physical activity-related mitochondrial adaptations, we functionally profiled skeletal muscle mitochondria in 51 inactive and 88 active men aged 20-93. Physical activity status confers partial protection against age-related decline in physical performance. Mitochondrial respiration remains unaltered in active participants, indicating that aging per se does not alter mitochondrial respiratory capacity. Mitochondrial r

SUBMITTER: Cefis M 

PROVIDER: S-EPMC11866497 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature