Optimizing bone health in people living with HIV: insights from a network meta-analysis of randomized controlled trials.

ABSTRACT:

Background

With life expectancy for people living with HIV (PLWH) approaching that of the general population, age-related conditions like osteoporosis are increasingly common. Both HIV infection and long-term antiretroviral therapy (ART), particularly tenofovir disoproxil fumarate (TDF), are associated with early-onset osteoporosis. Bisphosphonates are commonly used for treatment, but the optimal strategy for improving bone health in PLWH remains unclear.

Methods

We conducted a network meta-analysis (NMA) with component analysis of randomized controlled trials (RCTs) identified from Medline, EMBASE, Cochrane CENTRAL, Scopus, Web of Science and CINAHL EBSCO databases, from inception to December 1, 2024. The study included RCTs comparing zoledronate, alendronate, calcium and v

SUBMITTER: Wang JC 

PROVIDER: S-EPMC11876934 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature