Transanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical Trial.

ABSTRACT:

Importance

Previous studies have demonstrated the advantages of short-term histopathological outcomes and complications associated with transanal total mesorectal excision (TME) compared with laparoscopic TME. However, the long-term oncological outcomes of transanal TME remain ambiguous. This study aims to compare 3-year disease-free survival of transanal TME with laparoscopic TME.

Objective

To evaluate 3-year disease-free survival between transanal TME and laparoscopic TME in patients with rectal cancer.

Design, setting, and participants

This randomized, open-label, noninferiority, phase 3 clinical trial was performed in 16 different centers in China. Between April 2016 and June 2021, a total of 1115 patients with clinical stage I to III mid-low rectal cancer were en

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC11880948 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature