Nasopharyngeal Angiofibroma: Karyotyping Profile and Florescent In-Situ Hybridization Analysis with C-Myelocytomatosis, Tumor Suppressor p53 and CEP-X/Y Probes.

ABSTRACT: The chromosomal characterization of nasopharyngeal angiofibroma (NPF) of Indian origin seems important as it is consistently absent in literature. Routine karyotyping (G-banding) and fluorescence in situ hybridization (FISH) analysis was undertaken using CMYC, TP53 CEPX/Y probes in 9 cases of NPF wherein chromosomal characteristics were correlated with clinical parameters. Karyotype profile of venous sample from every case was normal. Following FISH analysis, 5 (55%) cases showed deleted CMYC allele while 4 (44%) showed deleted TP53. In addition, loss of Y centromere was evident in 1 case. Despite definite trends, no significant correlation with clinical parameters and FISH expression/ G-banding karyotyping could be appreciated. The peripheral blood karyotype cannot predict any significant

SUBMITTER: Patel V 

PROVIDER: S-EPMC11890675 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature