Gout management using uricase and sodium citrate hollow mesoporous nanomotors.

ABSTRACT: Uricase (UOx)-based gout treatments are generally limited due in part to the accumulation of H₂O₂ in an arthrosis environment characterized by a sluggish metabolism. Here we develop a self-cascade nanomotor with high efficiency toward simultaneous uric acid (UA) degradation and H₂O₂ elimination on the basis of UOx and sodium citrate loading in amine functionalized hollow mesoporous silica nanoparticles (AHMSNs). Due to the inherent asymmetry of AHMSNs, the developed nanomotors can be actuated by ionic diffusiophoresis induced by the enzymatic UA degradation, thus enlarging the diffusion range within the joint cavity. H₂O₂ generated during UA decomposition can be simultaneously eliminated by the loaded sodium citrate, resulti

SUBMITTER: Liu L 

PROVIDER: S-EPMC11890746 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature