Decreased intestinal abundance of <i>Akkermansia muciniphila</i> is associated with metabolic disorders among people living with HIV.

ABSTRACT:

Background

Previous studies have shown changes in gut microbiota after human immunodeficiency virus (HIV) infection, but there is limited research linking the gut microbiota of people living with HIV (PLWHIV) to metabolic diseases.

Methods

A total of 103 PLWHIV were followed for 48 weeks of anti-retroviral therapy (ART), with demographic and clinical data collected. Gut microbiome analysis was conducted using metagenomic sequencing of fecal samples from 12 individuals. Nonalcoholic fatty liver disease (NAFLD) was diagnosed based on controlled attenuation parameter (CAP) values of 238 dB/m from liver fibro-scans. Participants were divided based on the presence of metabolic disorders, including NAFLD, overweight, and hyperlipidemia. Akkermansia abundance in stool sample

SUBMITTER: Qian Z 

PROVIDER: S-EPMC11892071 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature