Distinct airway mycobiome signature in patients with pulmonary hypertension and subgroups.

ABSTRACT:

Background

The association between lung microbiome and pulmonary hypertension (PH) remain unknown. This study aims to define the airway mycobiome signature and its potential correlation with clinical parameters of PH.

Methods

Overall, 244 patients with PH and 120 healthy controls (CON) were recruited from three independent centers. The PH group was divided into subgroups not using antibiotics or corticosteroids (non-ANT/CORT), and those using ANT, CORT, or ANT + CORT within 1 month, and clinical classification (Groups 1, 3, and 4), World Health Organization functional class (I-IV), and disease severity based on mean pulmonary artery pressure or pulmonary vascular resistance levels for in-depth comparison.

Results

Distinct airway mycobiome profiles were observed in PH,

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11892250 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature