Can MRI radiomics distinguish residual adenocarcinoma from acellular mucin in treated rectal cancer?

ABSTRACT:

Background

We explored the use of MRI T2-weighted imaging (T2WI) radiomics to help distinguish acellular mucin from cellular mucin (residual tumor) to inform patient management.

Methods

This retrospective, multi-institutional study included consecutive patients with rectal adenocarcinoma containing mucin on restaging MRI from March 2012-January 2020. Radiologists segmented 3-mm-thick T2WI. Data were split into training (n = 122), validation (n = 40), and test (n = 42) sets. Sensitivity, specificity, PPV, NPV, and AUC of the developed radiomic models were investigated on the test set. Histopathology was the reference standard. Two radiologists independently reviewed 42 patients using a unique five-point Likert scale for the probability of cellular mucin. DeLong-Delong or McNe

SUBMITTER: Corines MJ 

PROVIDER: S-EPMC11892329 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature