Low Lung Function Is Associated with High Population Attributable Fraction for Cardiovascular Mortality.

ABSTRACT: Rationale: Chronic lung diseases are associated with increased risk of mortality due to coronary heart disease (CHD). Nonetheless, the population attributable fraction (PAF) of lung function impairment relative to other established cardiovascular risk factors is unclear. Objectives: To evaluate the PAF of low lung function for CHD mortality Methods: We harmonized and pooled lung function and clinical data across eight U.S. general population cohorts. Impaired lung function was defined as forced expiratory volume in 1 second (FEV₁) and/or forced vital capacity ≤ 95% predicted on baseline spirometry. The association between CHD mortality and risk factors was assessed using cause-specific proportional hazards and Fine-Gray proportional subdistribution hazard mo

SUBMITTER: Bhatt SP 

PROVIDER: S-EPMC11892675 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature