Role of vitamins in the pathogenesis and treatment of restless leg syndrome: A systematic review and meta-analysis.

ABSTRACT: We performed a meta-analysis to assess the role of vitamins in the possible pathogenesis and treatment of RLS (Restless Leg Syndrome). A systematic search of the PubMed, Cochrane, Embase, and Web of Science databases was conducted. Fifty-nine studies on the relationship between vitamins and RLS were included, as well as four randomized controlled trials (RCTs) on vitamin treatment of RLS. Compared with non-RLS patients, serum vitamin D levels were significantly lower both in primary (P =  0.009) and secondary (P =  0.003) RLS patients, and appeared to be positively correlated with disease severity. Serum folate levels were lower in pregnant RLS patients than in pregnant non-RLS patients (P =  0.007), but this phenomenon was not seen in non-pregnant RLS patients (P =  0.65). Vitamin B12 (P

SUBMITTER: Xu XM 

PROVIDER: S-EPMC11892881 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature