Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies.

ABSTRACT: Although the corticobasal syndrome was originally most closely linked with the pathology of corticobasal degeneration, the 2013 Armstrong clinical diagnostic criteria, without the addition of aetiology-specific biomarkers, have limited positive predictive value for identifying corticobasal degeneration pathology in life. Autopsy studies demonstrate considerable pathological heterogeneity in corticobasal syndrome, with corticobasal degeneration pathology accounting for only ∼50% of clinically diagnosed individuals. Individualized disease stage and progression modelling of brain changes in corticobasal syndrome may have utility in predicting this underlying pathological heterogeneity, and in turn improve the design of clinical trials for emerging disease-modifying therapies. The aim of this

SUBMITTER: Scotton WJ 

PROVIDER: S-EPMC11894806 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature