Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke.

ABSTRACT:

Importance

Tenecteplase is an alternative to alteplase for emergency treatment of acute ischemic stroke. However, limited data are available comparing their clinical effectiveness in routine clinical practice.

Objective

To compare short-term effectiveness and safety outcomes for patients with ischemic stroke treated with intravenous tenecteplase vs alteplase.

Design, setting, and participants

This comparative effectiveness study used data prospectively collected from July 1, 2020, through June 30, 2022, from the Get With The Guidelines-Stroke registry.

Exposure

Consecutive patients with ischemic stroke treated with either tenecteplase or alteplase within 4.5 hours from last known well time were included.

Main outcomes and measures

The primary end point w

SUBMITTER: Rousseau JF 

PROVIDER: S-EPMC11904722 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature