Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors.

ABSTRACT:

Introduction

Human metabolomics has made significant strides in understanding metabolic changes and their implications for human health, with promising applications in diagnostics and treatment, particularly regarding the gut microbiome. However, progress is hampered by issues with data comparability and reproducibility across studies, limiting the translation of these discoveries into practical applications.

Objectives

This study aims to evaluate the fit-for-purpose of a suite of human stool samples as potential candidate reference materials (RMs) and assess the state of the field regarding harmonizing gut metabolomics measurements.

Methods

An interlaboratory study was conducted with 18 participating institutions. The study allowed for the use of preferred analytical

SUBMITTER: Cruz AK 

PROVIDER: S-EPMC11904883 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature