Importance of N2BA Titin in Maintaining Cardiac Homeostasis and Its Role in Dilated Cardiomyopathy.

ABSTRACT:

Background

TTN (titin) is the third myofilament type of the cardiac sarcomere and performs important functions that include generating passive tension. Changes in TTN expression are associated with cardiac dysfunction, and TTN is one of the main genes linked to dilated cardiomyopathy (DCM). DCM is frequently associated with changes in the expression of N2BA (compliant cardiac TTN isoform), 1 of the 2 major TTN isoforms found in the heart (the other isoform being the N2B [stiff cardiac TTN isoform]). Whether altered expression of N2BA TTN causes DCM or is a secondary change remains unclear.

Methods

Here, we present a mouse model, the Ttn^Δ112-158 model, which specifically shortens the proline, glutamate, valine, lysine region of the N2BA isoform.

Results

Echo

SUBMITTER: van der Pijl R 

PROVIDER: S-EPMC11905908 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature