HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1.

ABSTRACT: Helper-component proteinase (HC-Pro), encoded by potyviruses, function as viral suppressors of RNA silencing (VSRs). Despite their conserved role, HC-Pros share approximately 40% similarity, implying potential differences in VSR efficiency, particularly in their ability to inhibit HEN1 methyltransferase activity. This study investigated the inhibitory potential of HC-Pros from different potyviruses in transgenic plants. P1/HC-Pro from turnip mosaic virus (P1/HC-Pro^Tu) exhibited the most potent inhibition of HEN1, followed by P1/HC-Pro from zucchini yellow mosaic virus (P1/HC-Pro^Zy), while P1/HC-Pro from tobacco etch virus (P1/HC-Pro^Te) showed the weakest inhibitory effect. These differential effectual effects corresponded to variations in unmethylated micro

SUBMITTER: Pan ZJ 

PROVIDER: S-EPMC11906750 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature