Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, ¹⁸F-SPAL-T-06 and ¹⁸F-C05-05.

ABSTRACT: ¹⁸F-SPAL-T-06 and ¹⁸F-C05-05 are two novel positron emission tomography (PET) radioligands targeting α-synuclein fibrils. Our study aimed to evaluate the biodistribution, safety, and radiation dosimetry of each tracer in humans. Biodistribution and radiation dosimetry studies were carried out with two healthy volunteers for each tracer, ¹⁸F-SPAL-T-06 (one female and one male volunteer, both aged 63 years) and ¹⁸F-C05-05 (one female and one male volunteer, aged 63 and 73 years, respectively). After injection of either tracer, dynamic PET images were acquired from head to upper thigh. Effective dose of each tracer was estimated using OLINDA/EXM Version 2.2. Injection of either of the tracers caused no adverse effects. Greatest uptake of both tracer

SUBMITTER: Goto R 

PROVIDER: S-EPMC11906790 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature