Hydrogen Peroxide-Releasing Hydrogel-Mediated Cellular Senescence Model for Aging Research.

ABSTRACT: Cellular senescence, a process that induces irreversible cell cycle arrest in response to diverse stressors, is a primary contributor to aging and age-related diseases. Currently, exposure to hydrogen peroxide is a widely used technique for establishing in vitro cellular senescence models; however, this traditional method is inconsistent, laborious, and ineffective in vivo. To overcome these limitations, we have developed a hydrogen peroxide-releasing hydrogel that can readily and controllably induce senescence in conventional 2-dimensional cell cultures as well as advanced 3-dimensional microphysiological systems. Notably, we have established 2 platforms using our hydrogen peroxide-releasing hydrogel for investigating senolytics, which is a promising innovation in anti-geronic therapy. Co

SUBMITTER: Wei S 

PROVIDER: S-EPMC11907071 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature