SARS-CoV-2 genomic evolution during a severe and long-lasting omicron infection under antiviral therapy.

ABSTRACT:

Background

Prolonged SARS-CoV-2 infection observed in immunocompromised individuals even in the presence of antiviral treatment provides opportunities for viruses to evolve in immune escape and drug-resistant variants.

Case presentation

A 72-year-old male with IgG4-related disease was admitted to the Emergency Department of a city Hospital in Milan and then transferred to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico in December 2023, due to respiratory distress due to SARS-CoV-2 infection diagnosed in November 2023. After 117 days since the onset of the infection, and two cycles of sotrovimab/remdesivir combined therapy, the clinical improvement allowed the hospital discharge, notwithstanding the persistent SARS-CoV-2 positivity. Fifteen days later, the patient

SUBMITTER: Bolis M 

PROVIDER: S-EPMC11907959 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature