Complex Sepsis Presentations, SEP-1 Compliance, and Outcomes.

ABSTRACT:

Importance

The Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Management Bundle (SEP-1) is supported by observational studies that report SEP-1 compliance is associated with lower mortality. Most studies, however, adjusted for limited confounders and provided little insight into why bundle-compliant care was not provided.

Objectives

To identify the clinical factors that complicate the diagnosis and management of sepsis and assess their association with SEP-1 compliance and mortality.

Design, setting, and participants

This retrospective cohort study was conducted among 590 adults with sepsis in the emergency department of 4 academic hospitals from January 1, 2019, to December 31, 2022. Patients' medical records were reviewed between September 2

SUBMITTER: Rhee C 

PROVIDER: S-EPMC11923707 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature