Acid-Triggered Dual-Functional Hydrogel Platform for Enhanced Bone Regeneration.

ABSTRACT: Stem cell implantation holds promise for enhancing bone repair, but risks of pathogen transmission and malignant cell transformation should not be ignored. Compared to stem cell implantation, recruitment of endogenous stem cells to injured sites is more critical for in situ bone regeneration. In this study, based on the acidic microenvironment of bone injury, an HG-AA_1:1-SDF-1α composite hydrogel with a dual-control intelligent switch function is developed by incorporating stromal cell-derived factor (SDF-1α), arginine carbon dots (Arg-CDs), and calcium ions (Ca²⁺) into the oxidized hyaluronic acid/gelatin methacryloyl (HG) hydrogel. The acidic microenvironment triggers the first switch (Schiff base bond is broken between HG-AA_1:1 and SDF-1α) of HG-AA₁

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC11923904 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature