Relative biological effectiveness of 31 meV thermal neutrons in peripheral blood lymphocytes.

ABSTRACT: The reported relative biological effectiveness (RBE) for thermal neutrons has a large range (5-51, for cytogenetic endpoints), which can confound radiation protection decision-making. To determine whether thermal neutron spectra can influence RBE, the RBE of reactor-derived thermal neutrons of average energy 31 meV was evaluated in human peripheral blood lymphocytes using two classical DNA double-strand break endpoints: the dicentric chromosome assay (DCA) and the cytokinesis-block micronucleus assay. Dose-response curves for 41 to 408 mGy revealed a preference for linear regression. Maximum RBE (RBEM) values of 6.7 ± 0.9 and 4.4 ± 0.7 were calculated for the DCA and the micronucleus assay, respectively. These 31 meV RBEM values were significantly lower than our prior results for 64 meV th

SUBMITTER: Paterson LC 

PROVIDER: S-EPMC11926985 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature