A Plasmid-Encoded Surface Polysaccharide Partly Blocks <i>Ceduovirus</i> Infection in Lactococci.

ABSTRACT: Bacteriophages (or phages) remain the leading cause of failure in dairy fermentations. Thereby, phage-resistant Lactococcus lactis and Lactococcus cremoris dairy starters are in continuous demand. In this work, our goal was to identify phage defense mechanisms against ceduoviruses encoded by two wild isolates of dairy origin named L. lactis IPLA517 and IPLA1064. These strains were previously subjected to experimental evolution to select derivatives that are resistant to the bacteriocin Lcn972. It was observed that the Lcn972^R derivatives became sensitive to phage infection; however, the underlying mechanism was not defined. The long-read sequencing technologies applied in this work reveal that all of the Lcn972^R derivatives shared the loss of a 41

SUBMITTER: Rendueles C 

PROVIDER: S-EPMC11942015 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature