Double-Layer Magnetic Microspheres with Dual Drug Delivery of Antibacterial and Maintenance Agents for the Treatment of <i>Candida albicans</i> Vaginitis.

ABSTRACT: Candida vaginitis (CV) is the most common fungal infection among gynecological diseases, caused by Candida albicans (C. albicans). Traditional treatment for CV has led to increased antibiotic resistance, complicating treatment and indiscriminately killing both pathogens and beneficial bacteria in the vagina. Additionally, the inconvenience of traditional vaginal administration and the short residence time of treatments pose significant challenges. We developed a safe and effective combination drug delivery platform featuring magnetic bilayer gel microspheres to combine antibacterial properties and maintain the balance of the microbial community. This platform was characterized through a series of in vitro tests evaluating its dissolution, adherence, and retentio

SUBMITTER: Li H 

PROVIDER: S-EPMC11947829 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature