Evaluation of a comprehensive set of normal tissue complication probability models for patients with head and neck cancer in an international cohort.

ABSTRACT:

Background/purpose

Normal tissue complication probability (NTCP) models can be used to guide radiation therapy (RT) decisions by estimating side-effect risks pretreatment to minimize (late) side-effects. Recently, a comprehensive individual toxicity risk (CITOR) profile of NTCP models addressing common side-effects in head and neck cancer (HNC) patients was developed. This study investigates the generalizability of these models in an international setting, with different treatment approaches and side-effect assessments, promoting their integration into more widespread clinical practice.

Materials/methods

From a prospective registry study, 407 HNC patients were included who were treated with definitive RT with or without systemic therapy between 2015 and 2022. NTCP models pre

SUBMITTER: de Vette SPM 

PROVIDER: S-EPMC11950982 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature