Visualizing Effective Connectivity in the Human Brain.

ABSTRACT: To enhance mechanistic understanding of effective connectivity in the human brain, we created a tool that links high-temporal resolution transcranial magnetic stimulation electroencephalography (TMS-EEG) with high-spatial resolution diffusion MRI. This tool, Surface to Tractography Real-time EEG Activation Mapping in 4 Dimensions (STREAM-4D), integrates electrophysiologic source estimation models from TMS-evoked potentials (TEPs) with structural connectivity models from diffusion MRI tractography. In a proof-of-principle application, we used STREAM-4D to analyze TMS-EEG and diffusion MRI tractography data in a neurotypical subject across three stimulation sites: premotor, parietal, and occipital cortex. STREAM-4D revealed extensive structural connections associated with the TMS-evoked sour

SUBMITTER: Atalay AS 

PROVIDER: S-EPMC11952297 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature