CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance.

ABSTRACT: Persistent systemic inflammation is associated with an elevated risk of cardiometabolic diseases. However, the characteristics of the innate and adaptive immune systems in individuals who develop these conditions remain poorly defined. Doublets, or cell-cell complexes, are routinely eliminated from flow cytometric and other immune phenotyping analyses, which limits our understanding of their relationship to disease states. Using well-characterized clinical cohorts, including participants with controlled human immunodeficiency virus (HIV) as a model for chronic inflammation and increased immune cell interactions, we show that circulating CD14+ monocytes complexed to CD3+ T cells are dynamic, biologically relevant, and increased in individuals with diabetes after adjusting for confounding fa

SUBMITTER: Obare LM 

PROVIDER: S-EPMC11952877 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature