Inflammatory burden index is correlated with increased depression: a population-based study.

ABSTRACT:

Background

Depression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating systemic inflammation. This study aims to explore the correlation between IBI and depression in the general population.

Methods

This cross-sectional study was designed to analyze the data from National Health and Nutrition Examination Survey (NHANES) during the period from 1999 to 2018. IBI was formulated as C-reactive protein×neutrophils/lymphocytes. The correlation between the prevalence of depression and IBI was explored through multivariate logistic regression analyses, as well as subgroup, interaction, restricted cubic spline (RCS) and sensitivity analyses.

Results

A total o

SUBMITTER: Shao X 

PROVIDER: S-EPMC11956433 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature