SMND-309 activates Nrf2 signaling to alleviate acetaminophen-induced hepatotoxicity and oxidative stress.

ABSTRACT:

Background

Acetaminophen (APAP) can be used for pain relief and fever alleviation, the overdose of which, however, may lead to the accumulation of N-acetyl-p-benzoquinone imine (NAPQI), inducing oxidative stress and liver damage. The natural compound SMND-309 has been shown to have hepatoprotective effects and potential antioxidant activity. However, its ability to alleviate acetaminophen-induced acute liver injury (AILI) has not been elucidated.

Objective

To explore the protective effect of the natural compound SMND-309 against AILI and the potential mechanism.

Methods

The AILI model was established using a mouse model and HepG2 cells for pathological evaluation and biochemical assays of mouse liver tissues to assess the level of liver injury. The effects of SMND-309

SUBMITTER: Dong Y 

PROVIDER: S-EPMC11957308 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature