Navigating the complexities of end-stage kidney disease (ESKD) from risk factors to outcome: insights from the UK Biobank cohort.

ABSTRACT:

Background

The global prevalence of end-stage kidney disease (ESKD) is increasing despite optimal management of traditional risk factors such as hyperglycaemia, hypertension, and dyslipidaemia. This study examines the influence of cardiorenal risk factors, socioeconomic status, and ethnic and cardiovascular comorbidities on ESKD outcomes in the general population.

Methods

This cross-sectional study analysed data from 502,408 UK Biobank study participants recruited between 2006 and 2010. Multivariable logistic regression models were fitted to assess risk factors for ESKD, with results presented as adjusted odds ratio (aOR) and 95% confidence intervals (95% CI).

Results

A total of 1191 (0.2%) of the study participants reported ESKD. Diabetes increased ESKD risk by 62% [

SUBMITTER: Kar D 

PROVIDER: S-EPMC11959863 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature