Fatty acid metabolism-derived prognostic model for lung adenocarcinoma: unraveling the link to survival and immune response.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is one of the most common malignant tumors globally, characterized by poor prognosis and high mortality. Abnormal fatty acid metabolism plays a crucial role in LUAD progression. This study aims to develop a prognostic model based on fatty acid metabolism to improve the overall prognosis of LUAD.

Materials and methods

Bioinformatics analyses were performed using TCGA and GEO datasets, supplemented by cell experiments. A total of 309 fatty acid metabolism-related genes were identified from MsigDB. Differentially expressed genes were analyzed using the 'limma' R package. A prognostic model was constructed using LASSO regression and validated with survival analyses via the 'survminer', 'survival', and 'pROC' R packages. The analysis included

SUBMITTER: Wu RZ 

PROVIDER: S-EPMC11965909 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature