A viral infection prediction model for patients with r/r B-cell malignancies after CAR-T therapy: a retrospective analysis.

ABSTRACT:

Background

Chimeric antigen receptor T cell (CAR-T) therapy for relapsed/refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL) and B cell non-Hodgkin lymphoma (B-NHL) patients has shown promising effects, but side effects such as viral infections have been observed.

Methods

A total of 45 patients with r/r B-ALL and r/r B-NHL were included in this retrospective study. Patient demographics were recorded, with the primary endpoint being viral infection within 3 months post CAR-T treatment. Univariate and multivariate logistic regression analyses and least absolute shrinkage and selection operator (LASSO) regression analysis were used to analyze independent factors. The patients were divided into a training cohort of 28 and a validation cohort of 17 to construct a predict

SUBMITTER: Guo S 

PROVIDER: S-EPMC11968754 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature