Distinct SIV-specific CD8⁺ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence.

ABSTRACT: Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing CD8⁺ T cell functions, which requires a deeper understanding of CD8⁺ T cells promoting HIV control. Here we identifiy an antigen-responsive TOX^hiTCF1⁺CD39⁺CD8⁺ T cell population with high expression of inhibitory receptors and low expression of canonical cytolytic molecules. Transcriptional analysis of simian immunodeficiency virus (SIV)-specific CD8⁺ T cells and proteomic analysis of purified CD8⁺ T cell subsets identified TOX^hiTCF1⁺CD39⁺CD8⁺ T cells as intermediate effectors that retained stem-like features with a lineage relationship with terminal effector T cells. TOX

SUBMITTER: Strongin Z 

PROVIDER: S-EPMC11969417 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature