Associations between amino acid levels and autism spectrum disorder severity.

ABSTRACT:

Background

Autism spectrum disorder (ASD) imposes a significant burden on both patients and society. Amino acid metabolism abnormalities are particularly relevant to ASD pathology due to their crucial role in neurotransmitter synthesis, synaptic function, and overall neurodevelopment. This study aims to explore the association between amino acid metabolic abnormalities and the severity of ASD by analyzing the amino acid concentrations in the blood of children with ASD.

Methods

Fasting peripheral blood samples were collected from 344 children with ASD, and amino acid concentrations were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS) while strictly following quality control measures. The association between amino acid concentrations and ASD severity w

SUBMITTER: Li J 

PROVIDER: S-EPMC11969702 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature