Dataset Information

Early Cold-stored Platelet Transfusion following Traumatic Brain Injury: A Randomized Clinical Trial.

ABSTRACT:

Objective

To determine the feasibility, efficacy, and safety of cold storage compared with room temperature (RT) platelet transfusion in patients with traumatic brain injury (TBI).

Background

Data demonstrating the safety and efficacy of cold-stored platelet (CSP) transfusion are lacking after TBI.

Methods

A phase 2, randomized, open-label clinical trial was performed at a single U.S. trauma center. Traumatic brain-injured patients with positive brain imaging and a need for platelet transfusion received up to 2 apheresis units of CSPs stored out to 14 days versus standard care RT platelet transfusion. The primary outcome was feasibility and the principal clinical outcome for efficacy and safety was the 6-month Glasgow Coma Scale-extended score.