X-Linked Cancer-Associated Polypeptide (XCP) from <i>lncRNA1456</i> Cooperates with PHF8 to Regulate Gene Expression and Cellular Pathways in Breast Cancer.

ABSTRACT: Recent studies have demonstrated that a subset of long "noncoding" RNAs (lncRNAs) produce functional polypeptides and proteins. In this study, we discovered a 132 amino acid protein in human breast cancer cells named XCP (X-linked Cancer-associated Polypeptide), which is encoded by lncRNA1456 (a.k.a. RHOXF1P3), a transcript previously thought to be noncoding. lncRNA1456 is a pancreas- and testis-specific RNA whose gene is located on chromosome X. We found that the expression of lncRNA1456 and XCP are highly upregulated in the luminal A, luminal B, and HER2 molecular subtypes of breast cancer. XCP modulates both estrogen-dependent and estrogen-independent growth of breast cancer cells by regulating cancer pathways, as shown in cell and xenograft models. XCP share

SUBMITTER: Gadad SS 

PROVIDER: S-EPMC11974697 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature