Age-Dependent Bi-Phasic Dynamics of Ly49⁺CD8⁺ Regulatory T Cell Population.

ABSTRACT: Aging is tightly associated with reduced immune protection but increased risk of autoimmunity and inflammatory conditions. Regulatory T cells are one of the key cells to maintaining immune homeostasis. The age-dependent changes in CD4⁺Foxp3⁺ regulatory T cells (Tregs) have been well documented. However, the nonredundant Foxp3^-CD8⁺ Tregs were never examined in the context of aging. This study first established clear distinctions between phenotypically overlapping CD8⁺ Tregs and virtual memory T cells. Then, we elucidated the dynamics of CD8⁺ Tregs across the lifespan in mice and further extended our investigation to human peripheral blood mononuclear cells (PBMCs). In mice, we discovered a bi-phasic dynamic shift in the frequ

SUBMITTER: Srinivasan S 

PROVIDER: S-EPMC11984669 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature