Modulation of the <i>ETV6::RUNX1</i> Gene Fusion Prevalence in Newborns by Corticosteroid Use During Pregnancy.

ABSTRACT: ETV6::RUNX1-positive pediatric acute lymphoblastic leukemia frequently has a prenatal origin and follows a two-hit model: a first somatic alteration leads to the formation of the oncogenic fusion gene ETV6::RUNX1 and the generation of a preleukemic clone in utero. Secondary hits after birth are necessary to convert the preleukemic clone into clinically overt leukemia. However, prenatal factors triggering the first hit have not yet been determined. Here, we explore the influence of maternal factors during pregnancy on the prevalence of the ETV6::RUNX1 fusion. To this end, we employed a nested interventional cohort study (IMPACT-BCN trial), including 1221 pregnancies (randomized into usual care, a Mediterranean diet, or mindfulness-based stress reduction) and determined

SUBMITTER: Benitez L 

PROVIDER: S-EPMC11988504 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature