Memory-promoting function of miR-379-5p attenuates CD8⁺ T cell exhaustion by targeting immune checkpoints.

ABSTRACT:

Background

MicroRNAs (miRNAs) are epigenetic regulators of T cell maturation and exhaustion. However, the mechanisms by which miRNAs influence T cell function in tumor environments remain unclear. This study focuses on miR-379-5p, which counteracts T cell exhaustion and enhances antitumor responses.

Methods

Native CD8⁺ T cells were isolated from the blood of healthy donors and subjected to chronic stimulation to induce exhaustion. RNA sequencing and miRNA sequencing were performed to identify differentially expressed miRNAs. These miRNAs underwent bioinformatics analyses, including DESeq enrichment, immune cell infiltration assessment, and patient prognostic outcomes in The Cancer Genome Atlas data sets to assess their potential involvement in T cell exhaustion an

SUBMITTER: Lin YZ 

PROVIDER: S-EPMC11997822 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature